C . elegans promoters in High nucleosome occupancy is encoded at X - linked gene
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High Nucleosome Occupancy Is Encoded at Human Regulatory Sequences
Active eukaryotic regulatory sites are characterized by open chromatin, and yeast promoters and transcription factor binding sites (TFBSs) typically have low intrinsic nucleosome occupancy. Here, we show that in contrast to yeast, DNA at human promoters, enhancers, and TFBSs generally encodes high intrinsic nucleosome occupancy. In most cases we examined, these elements also have high experimen...
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تاریخ انتشار 2010